Recombinant Nicastrin/NCSTN Monoclonal Antibody

This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

UNQ; PRO; ATAG; KIAA; RP11 517F; Anterior pharynx defective; RP11517F; NCSTN; ATAG1874; nicastrin; Anterior pharynx defective 2; APH 2; APH2; NCT; NICA; RP11 517F10.1; RP11517F101; KIAA0253; UNQ1874; PRO4317; RP11-517F10.1

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.