Recombinant Phospho-p53 (Ser15) Monoclonal Antibody
Product Specifications
Background
The p53 tumor suppressor protein is a multi-functional transcription factor that regulates cellular decisions regarding proliferation, cell cycle checkpoints, and apoptosis. The importance of p53 is underscored by its mutation in over 50% of human cancers. Mice that lack one or both copies of p53 also showed an increased incidence of tumors, which makes the p53 deficient mouse a model system for studying cancer generation and progression.
Abbreviation
TP53
UniProt
P04637
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues around Ser15 of the Human Phospho-p53
Target
BCC; LFS; TRP; BMFS; Antigen NY-CO; Tumor protein; Phosphoprotein p; Tumor suppressor p; Mutant tumor protein; Cellular tumor antigen p; Transformation related protein; BCC7; LFS1; P53; TRP53; TP53; BMFS5; Antigen NY-CO-13; Cellular tumor antigen p53; FLJ92943; Mutant tumor protein 53; p53 tumor suppressor; Phosphoprotein p53; Transformation related protein 53; Tumor protein 53; Tumor protein p53; Tumor suppressor p53; BCC7; LFS1; P53; TRP53; tumor protein p53; Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; p53; p53 tumor suppressor; P53; Phosphoprotein p53; Tp53; Transformation related protein 53; TRP53; Tumor protein 53; Tumor protein p53; Tumor suppressor p53
Clonality
Monoclonal
Clone
11A5
Conjugation
Unconjugated
Applications
WB
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling; Cancer
Purification
Protein A
Concentration
1 mg/mL
Dilution
WB 1:1000-1:5000
Buffer
10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
43 kDa
Observed Molecular Weight
43 kDa
Isotype
IgG
Available Sizes
Curated Selection
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