Recombinant Phospho-p70 S6 Kinase 1 (Thr389) Monoclonal Antibody
Product Specifications
Background
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.
Abbreviation
RPS6KB1
UniProt
P23443
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic phosphopeptide corresponding to residues around Thr389 of human p70 S6 kinase 1.
Target
RPS6KB; S6K-beta; PS6K; S6K; S6K-beta-1; S6K1; STK14A; p70 S6KA; p70 (S6K) -alpha; p70-S6K; p70-alpha; P70 S6K; RPS6KB1; p70S6KA;70 kDa ribosomal protein S6 kinase 1; alpha 1; alpha 2; KS6B1; p70 alpha; P70 beta 1; p70 ribosomal S6 kinase alpha; p70 ribosomal S6 kinase beta 1; P70 S6 Kinase; p70 S6 kinase alpha; p70 S6K-alpha; p70 (S6K) alpha; P70S6K; p70-S6K 1; P70S6K1; p70S6Kb; Ribosomal protein S6 kinase 70kDa polypeptide 1; Ribosomal protein S6 kinase beta 1; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; Serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A
Clonality
Monoclonal
Clone
12G12
Conjugation
Unconjugated
Applications
WB
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling; Signal Transduction; Metabolism
Purification
Protein A
Concentration
1 mg/mL
Dilution
WB 1:1000-1:200000
Buffer
0.2 μm filtered solution in PBS
Shipping Conditions
Ice bag
Storage Conditions
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
59 kDa
Observed Molecular Weight
60 kDa,80 kDa
Isotype
IgG
Available Sizes
Curated Selection
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