CD113/Nectin-3 Monoclonal Antibody

Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest) . It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation.

PRR; CDw; PPR; PVRL; Poliovirus receptor-like; Poliovirus receptor related; Poliovirus receptor related protein; PVRR; DKFZP566B; CD113; CDw113; DKFZP566B0846; FLJ90624; Nectin-3; Poliovirus receptor related 3; Poliovirus receptor related protein 3; Poliovirus receptor-like 3; Poliovirus Receptor-Related Protein 3; PPR3; PVRR3; PRR3; PVRL3; NECTIN3; Nectin-3; PRR3; CDw113

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.