Purified Anti-Human IL-10 Antibody[JES3-9D7]
Product Specifications
Background
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, prolifeRation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Abbreviation
IL-10
Gene ID
3586
UniProt
P22301
Host
Rat
Reactivity
Human
Immunogen
Recombinant Human IL-10 protein
Target
Interleukin; RP11-262N; CSIF; GVHDS; IL-10; IL10A; TGIF; IL10; Cytokine synthesis inhibitory factor; Interleukin-10; MGC126450; MGC126451; RP11-262N9.1
Clonality
Monoclonal
Clone
JES3-9D7
Conjugation
Unconjugated
Applications
FCM
Field of Research
Immunology; Cancer
Purification
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
PBS, pH 7.2. Contains 0.05% proclin 300.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Isotype
Rat IgG1, κ
Available Sizes
Curated Selection
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