Purified Anti-Human CD87 Antibody[H196-10E1]

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

PLAUR; CD87; U-PAR; UPAR; URKR; Monocyte activation antigen; suPAR; Urokinase Plasminogen Activator Surface Receptor; MO3; CD 87; CD87 antigen; MO 3; Monocyte activation antigen Mo3; Plasminogen activator receptor urokinase; Plasminogen activator urokinase receptor; U PAR; u plasminogen activator receptor; UPA receptor; u-plasminogen activator receptor form 2; Urinary plasminogen activator receptor; Urokinase plasminogen activator receptor; urokinase-type plasminogen activator (uPA) receptor