Cu(II)-Elesclomol
Product Specifications
UNSPSC Description
Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity[1].
Target Antigen
Apoptosis; Cuproptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cu-ii-elesclomol.html
Solubility
DMSO : 6.67 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
CN1[N-](C(C2)=O)[Cu+2]([S]=C3C4=CC=CC=C4)([S]=C1C5=CC=CC=C5)[N-](C2=O)N3C
Molecular Weight
462.05
References & Citations
[1]Brian B Hasinoff, et al. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). hem Pharmacol. 2015 Feb 1;93(3):266-76.|[2]Brian B Hasinoff, et al. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II). hem Pharmacol. 2015 Feb 1;93(3):266-76.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156376/Cu-II-Elesclomol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156376/Cu-II-Elesclomol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1224195-72-5
Available Sizes
Curated Selection
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