Cu (II) -Elesclomol

Cu (II) -Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu2+ (copper ions) . Cu (II) -Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu (II) -Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu (II) -Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu (II) -Elesclomol can be used in the study of cancer[1][2].

Product Specifications

CAS Number

[1224195-72-5]

UNSPSC

12352005

Target

Apoptosis; Cuproptosis; Reactive Oxygen Species (ROS) ; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cu-ii-elesclomol.html

Purity

99.99

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CN1[N-](C(C2)=O)[Cu+2]([S]=C3C4=CC=CC=C4)([S]=C1C5=CC=CC=C5)[N-](C2=O)N3C

Molecular Formula

C19H18CuN4O2S2

Molecular Weight

462.05

References & Citations

[1]Brian B Hasinoff, et al. Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu (II) . hem Pharmacol. 2015 Feb 1;93 (3) :266-76.|[2]Hasinoff BB, et al. The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu (II) . J Inorg Biochem. 2014 Aug;137:22-30.