MEK1/C-Raf-IN-1
MEK1/C-Raf-IN-1 (Compound 14d) is a MEK1/C-Raf inhibitor with IC50 values of 97 and 23 nM, respectively. MEK1/C-Raf-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
946128-76-3
UNSPSC
12352005
Target
MEK; Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mek1-c-raf-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=C(C(C)=C1CC3=C(F)C(NS(=O)(NC)=O)=CC=C3)C=CC(OC4=NC=CC=N4)=C2
Molecular Formula
C22H19FN4O5S
Molecular Weight
470.47
References & Citations
[1]Hyohdoh I, et al. Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties. ACS Med Chem Lett. 2013 Sep 22;4 (11) :1059-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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