PI3Kγ inhibitor AZ2

PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3) . PI3Kγ inhibitor AZ2 can be used for the research of inflammatory and immune diseases[1].

Product Specifications

CAS Number

[2231760-33-9]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pi3kγ-inhibitor-az2.html

Concentration

10mM

Purity

99.25

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=C2C(CN([C@H](C3CC3)C)C2=O)=CC(C4=C(C)N=C(NC(C)=O)S4)=C1

Molecular Formula

C20H23N3O2S

Molecular Weight

369.48

References & Citations

[1]Gangadhara G, et al. A class of highly selective inhibitors bind to an active state of PI3Kγ. Nat Chem Biol. 2019;15 (4) :348-357.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Available Sizes

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