Chlorpyrifos-d10
Chlorpyrifos-d10 is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.
Product Specifications
CAS Number
[285138-81-0]
UNSPSC
12352005
Hazard Statement
H301, H312, H315, H319, H330, H335, H410
Target
Cholinesterase (ChE)
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Purity
99.49
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : 100mg/mL (ultrasonic)
Smiles
S=P(OC([2H])([2H])C([2H])([2H])[2H])(OC1=NC(Cl)=C(Cl)C=C1Cl)OC([2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C9HD10Cl3NO3PS
Molecular Weight
360.65
Precautions
H301, H312, H315, H319, H330, H335, H410
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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