AIFM2 (CT) Peptide
Product Specifications
Background
AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type) . AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro) viral) cytosolic DNA, thus contributing to the onset of apoptosis
NCBI Gene ID
84883
Swiss Prot
Q9BRQ8
Accession Number
Q9BRQ8
Type
Peptides
Concentration
200 ug/mL
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Shipping Conditions
Blue Ice
Storage Conditions
Store AIFM2 (CT) Peptide at -20˚ C, stable for one year.
Applications Notes
AIFM2 (CT) Peptideis used for blocking the activity of theAIFM2 (CT) Antibody
NCBI Official Name
Apoptosis inducing factor mitochondria associated
NCBI Organism
Homo sapiens
Background Reference 01
Dai et al. Biochem Biophys Res Commun. 2020; 523 (4) :966-971
Background Reference 02
Bersuker et al. Nature 2019; 575 (7784) :688-692
Background Reference 03
Doll et al. Nature 2019; 575 (7784) :693-698
Background Reference 04
Chen et al. J Mol Neurosci 2019; 68 (2) : 304-310
Background Reference 05
Gong et al. J Biol Chem 2007; 282 (41) :30331-30340
Other Product Names
AIMF2
Tested Applications
Blocking
Species
Human
Protein ID
74752283
Physical Properties
Liquid
Curated Selection
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