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AIFM2 (CT) Peptide

Product Specifications

Background

AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type) . AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro) viral) cytosolic DNA, thus contributing to the onset of apoptosis

NCBI Gene ID

84883

Swiss Prot

Q9BRQ8

Accession Number

Q9BRQ8

Type

Peptides

Concentration

200 ug/mL

Buffer

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Shipping Conditions

Blue Ice

Storage Conditions

Store AIFM2 (CT) Peptide at -20˚ C, stable for one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=9653P

Applications Notes

AIFM2 (CT) Peptideis used for blocking the activity of theAIFM2 (CT) Antibody

NCBI Official Name

Apoptosis inducing factor mitochondria associated

NCBI Organism

Homo sapiens

Background Reference 01

Dai et al. Biochem Biophys Res Commun. 2020; 523 (4) :966-971

Background Reference 02

Bersuker et al. Nature 2019; 575 (7784) :688-692

Background Reference 03

Doll et al. Nature 2019; 575 (7784) :693-698

Background Reference 04

Chen et al. J Mol Neurosci 2019; 68 (2) : 304-310

Background Reference 05

Gong et al. J Biol Chem 2007; 282 (41) :30331-30340

Other Product Names

AIMF2

Tested Applications

Blocking

Species

Human

Protein ID

74752283

Physical Properties

Liquid

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