LIX Recombinant Protein

CXCL6, also known as GCP-2 in humans and LIX in mice, is a connective tissue-derived CXC chemokine that contains the four conserved cysteine residues shared by CXC chemokines and the ‘ELR’ motif responsible for CXCR1 and CXCR2 receptor signaling. Constitutively expressed in monocytes, platelets, endothelial cells and mast cells, CXCL6 selectively chemoattracts neutrophils and has been shown to exert anti-angiogenic activity. Human GCP-2 and murine LIX respectively exhibit murine and human cell cross-reactivity. There are two naturally occurring variants of murine LIX, the 78 amino-acid-length LIX 1-78 (GCP-2) and the 70 amino-acid-length LIX 9-78 (GCP-2) .

The lyophilized LIX recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted LIX is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing LIX recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.