IGF-BP1 Recombinant Protein

Product Specifications

Background

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A) .

NCBI Gene ID

3484

Swiss Prot

P08833

Accession Number

NP_000587.1

Type

Recombinant Proteins

Source

E. coli

Field of Research

Cancer, Growth Factors, Immunology, Signal Transduction

Shipping Conditions

Room Temp

Storage Conditions

The lyophilized IGF-BP1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IGF-BP1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IGF-BP1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.