IFN lamda 1 Recombinant Protein

IFN λ -1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-λ R1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces anti-viral defense similar but distinct than the type I Interferons. (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77) . Recombinant human IFN-λ 1 is a 19.8 kDa protein containing 178 amino acid residues.

The lyophilized IFN lamda 1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IFN lamda 1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IFN lamda 1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.