TSG Recombinant Protein

Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 199 amino acid 22.2 kDa protein containing the BMP/TGFβ binding portion of the full length TSG protein.

The lyophilized TSG recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TSG is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TSG recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.