STIM-1 Antibody

Product Specifications

Background

STIM-1 is a component of the Ca sensor/channel. It associates with ORAI-1 and form a essential complex involved in store-operated channels. STIM1 activates Ca (2+) influx via Orai1 channels. Expression of STIM and Orai proteins are found in many cell types and knock-out mice lack viability.

NCBI Gene ID

6786

Swiss Prot

Q13586

Accession Number

EAX02580

Host

Sheep

Reactivity

Human

Immunogen

A synthetic peptide corresponding to a region near the N-terminus.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Cancer

Purification

Affinity Purified

Concentration

Batch dependent

Modification

None

Shipping Conditions

Dry Ice

Fragment

IgG

Applications Notes

ELISA, Western (immuno) blotting, Immunostaining (in testing)

Symbol

STIM1

NCBI Official Name

Stromal interaction molecule 1

NCBI Organism

Homo sapiens

Background Reference 01

Williams RT, Senior PV, Van Stekelenburg L, Layton JE, Smith PJ, Dziadek MA., Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation., Biochim Biophys Acta. 2002 Apr 1;1596 (1) :131-137

Background Reference 02

Dziadek MA, Johnstone LS., Biochemical properties and cellular localisation of STIM proteins., Cell Calcium. 2007 Aug;42 (2) :123-32.

Background Reference 03

Frischauf I, Schindl R, Derler I, Bergsmann J, Fahrner M, Romanin C., . The STIM/Orai coupling machinery., Channels (Austin) . 2008 Jul-Aug;2 (4) :261-8