Dopamine b-Hydroxylase Antibody
Product Specifications
Background
Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. The expression of DBH is elevated during stress.
NCBI Gene ID
1621
Swiss Prot
P09172
Accession Number
P09172
Host
Sheep
Reactivity
Human, Rat, Sheep, Bovine
Immunogen
DBH polyclonal antibody was raised against a synthetic peptide from the N-terminal region of human DBH, conjugated to keyhole limpet hemocyanin.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For long term storage –80˚ C is recommended, but shorter term storage at –20˚ C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Calculated Molecular Weight
75
Specificity
Dopamine b-Hydroxylase, NT antibody is specific immunolabeling of the ~75k DBH protein in Western blots of human adrenal medulla.
Applications Notes
Applications include Dot Blots (DB) and Western Blots (WB) . Sheep anti-DBH recognizes DBH in bovine, human, monkey and rat tissues. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Symbol
DBH
NCBI Official Name
Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NCBI Organism
Homo sapiens
Background Reference 01
Sabban, E.L., Kvetnansky, R. "Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events, " Trends Neurosci. 24 (2001) 91 - 98.
Background Reference 02
Nagatsu, I, Kobayashi, K, Fujii, T, Komori, K, Sekiguchi, K, Titani, K, Fujita, K, and Nagatsu, T. "Antibodies raised against different oligopeptide segments of human dopamine-β -hydroxylase, " Neuroscience Letters, 120 (1990) 141 - 145.
Tested Applications
WB
Protein ID
158517849
Physical Properties
Liquid
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