Dopamine Decarboxylase Antibody
Product Specifications
Background
Aromatic L-amino acid decarboxylase (AADC; DOPA decarboxylase; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin. It is also involved in the biosynthesis of trace amines.
NCBI Gene ID
280762
Swiss Prot
P27718
Accession Number
P27718
Host
Rabbit
Reactivity
Rat, Bovine
Immunogen
DOPA Decarboxylase polyclonal antibody was raised against a SDS denatured, recombinant bovine aromatic DDC expressed in E. coli and purified from inclusion bodies.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity Purified
Concentration
Batch dependent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For long term storage –80˚ C is recommended, but shorter term storage at –20˚ C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=XPS-2000
Calculated Molecular Weight
55
Specificity
Dopamine Decarboxylase antibody is specific immunolabeling of the ~55k DDC protein in Western blots of rat adrenal medulla.
Applications Notes
Applications include Dot Blots (DB) and Western Blots (WB) . Recognizes DDC in rat adrenal medulla and caudate. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Symbol
DDC
NCBI Official Name
Dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Organism
Bos taurus
Background Reference 01
Haycock, J.W., Becker, L., Ang, L., Furukawa, Y., Hornykiewicz, O., and Kish, S.J., "Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum, " J. Neurochem. 87 (2003) 574 - 585.
Background Reference 02
Waymire, J.C. and Haycock, J.W. "Lack of regulation of aromatic L-amino acid decarboxylase in intact bovine chromaffin cells, " J. Neurochem. 81 (2002) 589 - 593.
Background Reference 03
Berry, M.D., Juorio, A.V., Li, X.M., and Boulton, A.A. "Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme, " Neurochem. Res. 21 (1996) 1075 -1087.
Tested Applications
WB
Protein ID
125987819
Physical Properties
Liquid
Curated Selection
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