Interferon-a Receptor (phospho Ser535 / 539) Antibody
Product Specifications
Background
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon-alpha Receptor (IFNAR1) . Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
NCBI Gene ID
3454
Swiss Prot
P17181
Accession Number
P17181
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine
Immunogen
IFNAR1 (Ser535/539) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the human Phospho-Ser535, 539 Type I Interferon-a Receptor Subunit 1 (IFNAR1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Phospho-Specific
Purification
Affinity Purified
Concentration
Batch dependent
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
For long term storage –80˚ C is recommended, but shorter term storage at –20˚ C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=XPS-1014
Calculated Molecular Weight
110-130
Specificity
Interferon a Receptor antibody is specific for IFNAR1 phosphorylated at Ser535,539.
Applications Notes
Applications include Dot Blots (DB) and Western Blots (WB) . Suitability for Immunohistochemistry (IHC) has not yet been determined. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Symbol
IFNAR1
NCBI Official Name
Interferon (alpha, beta and omega) receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Suresh Kumar, K.G., Tang, W., Ravindranath, A.K., Clark, W.A., Croze, E., Fuchs, S.Y., "SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor, " The EMBO Journal, 22 (2003), 5480-5490.
Background Reference 02
Kirkwood, J., "Cancer immunotherapy: the interferon- experience, " Semin. Oncol., 29 (2002) 18-26.
Background Reference 03
Biron, C.A., "Interferons alpha and beta as immune regulators-a new look, " Immunity, 14 (2001) 661-664.
Background Reference 04
Stark, G.R., Kerr, I.M., Williams, B.R., Silverman, R.H. and Schreiber, R.D. "How cells respond to interferons." Annu. Rev. Biochem., 67 (1998) 227-264.
Tested Applications
WB, IHC
Protein ID
90110827
Physical Properties
Liquid
Curated Selection
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