RANTES Antibody [5B3-D5]

Product Specifications

Background

RANTES is a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. It binds to CCR1, CCR3, CCR4 and CCR5 and is one of the major HIV suppressive factors produced by CD8+ T cells. Recombinant RANTES protein induces a dose dependent inhibition of different strains of HIV 1, HIV 2, and simian immunodeficiency virus (SIV) . It is T cell and macrophage specific, induced by mitogens, and belongs to the intercrine beta (chemokine CC) family.

NCBI Gene ID

6352

Swiss Prot

P13501

Accession Number

P13501

Host

Mouse

Reactivity

Human

Immunogen

Monoclonal antibody against human RANTES designated as VL-1 was purified from ascites fluid on a Protein A affinity column.

Clonality

Monoclonal

Clone

5B3-D5

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Chemokines & Cytokines

Concentration

Batch dependent

Modification

None

Shipping Conditions

Room Temp

Storage Conditions

RANTES lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20˚ C. Reconstitute in sterile water to a concentration of 0.1 - 1.0 mg/mL. The antibody is stable for at least six weeks at 2-4˚ C when reconstituted.

Fragment

RANTES antibody was derived form BALB/c mice and belongs to the IgG2b isotype.

Symbol

CCL5

NCBI Official Name

Chemokine (C-C motif) ligand 5

NCBI Organism

Homo sapiens

Other Product Names

Regulated upon activation normally T expressed and presumably secreted, CCL5, TCP228, SISd, D17S136E, SCYA5, C-C motif chemokine 5, EoCP, eoCP, RANTES, SIS-delta