TRAIL Antibody

Product Specifications

Background

Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain".

NCBI Gene ID

8743

Swiss Prot

P50591

Accession Number

P50591

Host

Rabbit

Reactivity

Human

Immunogen

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hTRAIL/Apo2L (humanTRAIL/Apo2L) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies, Antibody Pairs

Field of Research

Cancer, Apoptosis

Purification

Anti-hTRAIL/Apo2L specific antibody was purified by affinity chromatography employing immobilized hTRAIL/Apo2L matrix.

Concentration

Batch dependent

Modification

None

Shipping Conditions

Room Temp

Storage Conditions

TRAIL/Apo2L antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.