Osteoprotegerin Antibody
Product Specifications
Background
Osteoprotegerin (OPG) is a member of the TNF receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of the gene have been reported, but their full length nature has not been determined.
NCBI Gene ID
4982
Swiss Prot
O00300
Accession Number
O00300
Host
Rabbit
Reactivity
Human
Immunogen
Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hOPG (human Osteoprotegrin) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies, Antibody Pairs
Field of Research
Signal Transduction
Purification
Anti-hOPG specific antibody was purified by affinity chromatography employing immobilized hOPG matrix.
Concentration
Batch dependent
Modification
None
Shipping Conditions
Room Temp
Storage Conditions
Osteoprotegerin antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.
Symbol
TNFRSF11B
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 11b
NCBI Organism
Homo sapiens
Other Product Names
OPG, TR1, OCIF, OPG, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor
Tested Applications
ELISA, WB
Protein ID
322510101
Physical Properties
Lyophilized
Curated Selection
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