FLIP Antibody [Dave-2]
Product Specifications
Background
FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.
NCBI Gene ID
8837
Swiss Prot
O15519
Accession Number
2253679
Host
Rat
Reactivity
Human, Mouse
Immunogen
Recombinant human FLIP (aa 1-480) .
Clonality
Monoclonal
Clone
Dave-2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Concentration
1 mg/ml
Buffer
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Fragment
IgG2a
Specificity
Recognizes an epitope (aa 1-200) present in both short (FLIPS) and long (FLIPL) splice variants of human and mouse FLIP.
Applications Notes
Immunoprecipitation: (1-2ug/ml) . Western Blot: (1-5ug/ml) . Optimal conditions must be determined individually for each application.
Symbol
CFLAR
NCBI Official Name
CASP8 and FADD-like apoptosis regulator
NCBI Organism
Homo sapiens
Other Product Names
I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1
Tested Applications
IP, WB
Protein ID
AAC51622
Physical Properties
Liquid
Curated Selection
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