B7H3 Antibody [7B3]

Product Specifications

Background

CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1) . CD276 mRNA is widely expressed, but its protein expression is usually rather low (2) . CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3) . In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4) . It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.

NCBI Gene ID

80381

Swiss Prot

Q5ZPR3

Accession Number

NP_001019907

Host

Mouse

Reactivity

Human

Immunogen

B7-H3 antibody was raised against the extracellular domain of human B7-H3

Clonality

Monoclonal

Clone

7B3

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

B7-H3 Antibody is supplied as protein A purified IgG1.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Buffer

B7-H3 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

B7-H3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=RF16094

Fragment

IgG1, k

Symbol

CD276

Positive Control 2

Cat. No. 17-010 - HEK293 Cell Slide

NCBI Official Name

CD276

NCBI Organism

Homo sapiens

Background Reference 01

Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2:269-74.

Background Reference 02

Sun M, Richards S, Prasad DV, et al. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168:6294-7.

Background Reference 03

Yi KH and Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 2009; 229:145-51.

Background Reference 04

Wang L, Kang FB, and Shan BE. B7-H3-mediated tumor immunology: friend or foe?. Int J Cancer 2014; 134:2764-71.

Other Product Names

B7-H3 Antibody: CD276 molecule, B7H3, B7RP-2, 4Ig-B7-H3, CD276

Tested Applications

ELISA, IHC-P, ICC, IF, Flow

Protein ID

67188443

Physical Properties

Liquid

Available Sizes

Curated Selection

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