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LAG3 Antibody [1G4]

Product Specifications

Background

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2) . It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4) . LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

NCBI Gene ID

3902

Swiss Prot

P18627

Accession Number

NP_002277

Host

Mouse

Reactivity

Human

Immunogen

LAG-3 antibody was raised against the extracellular domain of human LAG-3

Clonality

Monoclonal

Clone

1G4

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

LAG-3 Antibody is supplied as protein A purified IgG1.

Positive Control

Cat. No. 1331 - Human Lymphoma Tissue Lysate

Concentration

1 mg/mL

Buffer

LAG-3 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

LAG-3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=RF16089

Fragment

IgG1, k

Symbol

LAG3

Positive Control 2

Cat. No. 1306 - Human Spleen Tissue

NCBI Official Name

Lymphocyte activating 3

NCBI Organism

Homo sapiens

Background Reference 01

Huard B, Tournier M, Hercend T, et al. Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes. Eur J Immunol 1994; 24:3216–21.

Background Reference 02

Triebel F. LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. Trends Immunol 2003; 24:619–22.

Background Reference 03

Workman CJ, Wang Y, El Kasmi KC, et al. LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol. 2009; 182:1885–91.

Background Reference 04

Workman CJ, Vignali DA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 2003; 33:970–9.

Other Product Names

LAG3 Antibody: lymphocyte activating 3, LAG-3, CD223

Tested Applications

ELISA, WB, IHC-P, ICC, IF, Flow

Protein ID

167614500

Physical Properties

Liquid

Available Sizes

Curated Selection

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