PDL2 Antibody [7C7]

Product Specifications

Background

PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC) . T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.

NCBI Gene ID

80380

Swiss Prot

P9BQ51

Accession Number

NP_079515

Host

Mouse

Reactivity

Human

Immunogen

PD-L2 antibody was raised against the extracellular domain of human PD-L2.

Clonality

Monoclonal

Clone

7C7

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

PD-L2 Antibody is supplied as protein A purified IgG1.

Positive Control

Cat. No. 1207 - Raji Cell Lysate

Concentration

1 mg/mL

Buffer

PD-L2 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PD-L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG1

Symbol

PDCD1LG2

Positive Control 2

Cat. No. 1315 - Human Tonsil Tissue

NCBI Official Name

Programmed cell death 1 ligand

NCBI Organism

Homo sapiens

Background Reference 01

Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.

Background Reference 02

Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.

Background Reference 03

LaGier J and Pober JS. Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1) . Hum. Immunol. 2006; 67:568-78.