SARS-CoV-2 (COVID-19) Spike P681R Antibody [5H4C5] (Delta Variant)

Product Specifications

Background

SARS-CoV-2 delta variant, a variant of concern (VOC), known as B.1.617.2, was detected in India in October of 2020. However, it rapidly spread all over of the world and now it is the dominant variant in the world, which account for more than 99% of the cases. This variant carries at least 13 mutations in spike protein across the sub lineages, including L452R, D614G, P681R and K417N, which can increase the affinity to the human ACE2 receptor. Enhanced transmission of the Delta variant was observed globally, which is at least 2.5 times more contagious as the other variants. The Delta variant affects the effectiveness of COVID19 vaccine and is resistant to neutralization to some extent.

NCBI Gene ID

43740568

Swiss Prot

P0DTC2

Accession Number

QHD43416

Host

Mouse

Reactivity

Virus

Immunogen

PM-9677

Clonality

Monoclonal

Clone

5H4C5

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease, COVID-19

Purification

Anti-SARS-CoV-2 Spike P681R (Delta Variant) antibody is immunoaffinity chromatography purified IgG.

Concentration

1 mg/mL

Homology

Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (25%)

Buffer

SARS-CoV-2 Spike P681R (Delta Variant) antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SARS-CoV-2 Spike P681R (Delta Variant) antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG1

Specificity

It can only detect SARS-CoV-2 Delta Variant Spike S1 protein and does not cross-react with the spike protein of other variants.

Symbol

NCBI Official Name

Surface glycoprotein

NCBI Organism

Severe acute respiratory syndrome coronavirus 2

Background Reference 01

Zhang et al. JAMA 2021, 325 (13) : 1324-26.

Background Reference 02

Reardon. Nature 2021.

Background Reference 03

Delphine. Nature 2021, 596 (7871) : 276-280.

Other Product Names

Anti-SARS-CoV-2 Spike P681R (Delta Variant) antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein, Delta variant