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SARS-CoV-2 (COVID-19) Spike 26P Antibody [1C3H9]

Product Specifications

Background

In January of 2021 a new lineage of SARS-CoV-2, known as P.1 and named Gamma variant, was discovered in Japan and later spread in Brazil. It is considered a VOC (variant of concern) . This variant carries 10 mutations in spike protein, including N501Y, E484K and K417T in RBD, which can increase the affinity to the human ACE2 receptor. Enhanced transmission of the Gamma variant (P.1 lineage) was observed globally, which is 3.5 times more contagious as the original one. The Gamma variant affects the effectiveness of COVID19 vaccine and is resistant to neutralization to some extent due to the immune escape E484K mutation.

NCBI Gene ID

43740568

Swiss Prot

P0DTC2

Accession Number

QHD43416

Host

Mouse

Reactivity

Virus

Immunogen

PM-9583

Clonality

Monoclonal

Clone

1C3H9

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease, COVID-19

Purification

Anti-SARS-CoV-2 Spike 26P antibody is Protein A purified.

Concentration

1 mg/mL

Homology

Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (36.4%)

Buffer

SARS-CoV-2 Spike 26P antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SARS-CoV-2 Spike 26P antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=PM-9583

Fragment

IgG2b

Specificity

It detects Spike S1 proteins of SARS-CoV-2 WT and variants except gamma variant.

Symbol

S

NCBI Official Name

Surface glycoprotein

NCBI Organism

Severe acute respiratory syndrome coronavirus 2

Background Reference 01

Voloch et al. Journal of Virology 2021, 95 (10) : e00119-21.

Background Reference 02

Wang et al. Cell Host & Microbe 2021, 29 (5) : 747-751.

Background Reference 03

Wang et al. Nature 592, 616-622.

Other Product Names

SARS-CoV-2 Spike 156-157EF antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein

Tested Applications

ELISA, WB

Protein ID

1791269090

Physical Properties

Liquid

Available Sizes

Curated Selection

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