Vinculin Antibody [7E10]

Product Specifications

Background

Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1) . Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2) . Expression of vinculin were shown to be affected by the level of actin expression (2,3) . Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4) . Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5) .

NCBI Gene ID

7414

Accession Number

NP_003364

Host

Mouse

Reactivity

Human, Mouse, Rat, Rabbit, Chicken

Clonality

Monoclonal

Clone

[7E10]

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

Vinculin antibody is purified via Protein A prification.

Positive Control

Cat. No. 1216 - PC-3 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (100%)

Buffer

Vinculin Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Vinculin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.

Symbol

VCL

NCBI Official Name

Vinculin

NCBI Organism

Homo sapiens

Background Reference 01

Burridge et al. Annu. Rev. Cell Biol.1988; 4:487-525.

Background Reference 02

Gilmore et al. J. Cell Sci. 1992; 103:719-31.

Background Reference 03

Deakin et al. PLoS One 2012; 7:e37990.

Background Reference 04

Goldmann et al. Cell Biol. Int. 2013; Feb 1.

Other Product Names

CMD1W, CMH15, Metavinculin, MVCL

Tested Applications

ELISA, WB

Protein ID

4507877

Physical Properties

Liquid

Available Sizes

Curated Selection

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