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GLUL Monoclonal Antibody

Product Specifications

Background

GLUL Monoclonal Antibody: Glutamate ammonia ligase (GLUL) belongs to the glutamine synthetase family and catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. GLUL is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Recent studies have suggested that elevated levels of GLUL may be an early marker for hepatocellular carcinoma.

NCBI Gene ID

2752

Accession Number

NP_002056

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Mouse monoclonal GLUL antibody was raised against a 15 amino acid peptide near the amino terminus of human GLUL.

Clonality

Monoclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

GLUL Monoclonal Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

GLUL Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

GLUL Monoclonal antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Calculated Molecular Weight

Predicted: 41 kDa

Fragment

IgG1

Applications Notes

GLUL antibody can be used for detection of GLUL by Western blot at 0.5 - 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.

Symbol

GLUL

NCBI Official Name

Glutamate-ammonia ligase

NCBI Organism

Homo sapiens

Background Reference 01

Wang Y, Kudoh J, Kubota R, et al. Chromosomal mapping of a family of human glutamine synthetase genes: functional gene (GLUL) on 1q25, pseudogene (GLULP) on 9p13, and three related genes (GLULL1, GLULL2, GLULL3) on 5q33, 11p15, and 11q24.

Background Reference 02

Long J, Lang ZW, Wang HG, et al. Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected small hepatocellular carcinomas. Hepatobiliary Pancreat. Dis. Int. 2010; 9:296-305.

Other Product Names

GLUL Monoclonal Antibody: Glutamate ammonia ligase, glutamine synthase, glutamate decarboxylase, GLNS, GS, PIG43, PIG59, cell proliferation-inducing protein 59

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

19923206

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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