CD4 Antibody [8G1B12]

Product Specifications

Background

CD4 Monoclonal Antibody: CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.

NCBI Gene ID

920

Swiss Prot

P01730

Accession Number

NP_000607

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

PM-5203

Clonality

Monoclonal

Clone

8G1B12

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

CD4 Monoclonal Antibody is Protein A purified.

Positive Control

Cat. No. 1462 - Rat Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

CD4 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CD4 monoclonal antibody can be stored at -20˚ C, stable for one year.

Fragment

IgG1

Isoform

Human CD4 has one isoform (458aa, 51kD) . Mouse CD4 has two isoforms, including isoform 1 (457aa, 51kD) and isoform 2 (217aa, 24.5kD) . Rat CD4 has one isoform (457aa, 51kD) . PM-5203 can detect human, mouse and rat.