Bim Antibody [1C2H4]

Product Specifications

Background

Bim Monoclonal Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

NCBI Gene ID

10018

Swiss Prot

O43521

Accession Number

NP_619527

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim.

Clonality

Monoclonal

Clone

1C2H4

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Bim Monoclonal Antibody is Protein A purified.

Positive Control

Cat. No. 95-107 - Bim Recombinant Protein

Concentration

1 mg/mL

Buffer

Bim Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Bim monoclonal antibody can be stored at -20˚ C, stable for one year.

Fragment

IgG1

Symbol

BCL2L11

Positive Control 2

Cat. No. 17-004 - K-562 Cell Slide

NCBI Official Name

BCL2-like 11 (apoptosis facilitator)

NCBI Organism

Homo sapiens

Background Reference 01

O'Connor L, Strasser A, O'Reilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998; 17:384-395.

Background Reference 02

Hsu SY, Lin P, and Hsueh AJ BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 1998; 12:1432-40.