Bim Antibody [1C2C8]

Product Specifications

Background

Bim Monoclonal Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

NCBI Gene ID

10018

Swiss Prot

O43521

Accession Number

NP_619527

Host

Mouse

Reactivity

Human, Mouse

Immunogen

Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim.

Clonality

Monoclonal

Clone

1C2C8

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer

Purification

Bim Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Positive Control

Cat. No. 95-107 - Bim Recombinant Protein

Concentration

1 mg/mL

Buffer

Bim Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Bim monoclonal antibody can be stored at -20˚ C, stable for one year.

Fragment

IgG1

Symbol

BCL2L11

Positive Control 2

Cat. No. 17-004 - K-562 Cell Slide

NCBI Official Name

BCL2-like 11 (apoptosis facilitator)

NCBI Organism

Homo sapiens

Background Reference 01

O'Connor L, Strasser A, O'Reilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998; 17:384-395.

Background Reference 02

Hsu SY, Lin P, and Hsueh AJ BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 1998; 12:1432-40.