DC-SIGN Antibody [8B6]

Product Specifications

Background

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

NCBI Gene ID

30835

Swiss Prot

Q9NNX6

Accession Number

Q9NNX6

Host

Mouse

Reactivity

Human

Immunogen

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Clonality

Monoclonal

Clone

8B6

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease

Purification

DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Positive Control

Cat. No. 1384 - Human Uterus Tissue Lysate

Concentration

1 mg/mL

Buffer

DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DC-SIGN monoclonal antibody can be stored at -20˚ C, stable for one year.

Fragment

IgG1, k

Symbol

CD209

Positive Control 2

Cat. No. 1369 - Human Lymph node Tissue Lysate

NCBI Official Name

CD209 molecule

NCBI Organism

Homo sapiens

Background Reference 01

Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97.

Background Reference 02

Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001;75:4664-72.

Background Reference 03

Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85.