Bcl-2 Antibody [10C4]
Product Specifications
Background
Bcl-2 is a 26 kDa member of the family of proteins involved in regulation of programmed cell death, or apoptosis. It is expressed in a variety of both normal and neoplastic tissues and appears to be membrane-bound since it is detectable in crude membrane and nuclear fractions, but not in the soluble fraction of cell lysates. Overexpression of Bcl-2 can prevent apoptosis, while formation of heterodimers with Bax, another Bcl-2-related protein, inhibits Bcl-2’s ability to promote cell survival.
NCBI Gene ID
12043;24224
Swiss Prot
P10417
Accession Number
P10417
Host
Mouse
Reactivity
Mouse, Rat
Immunogen
Murine Bcl-2 peptide (a.a. 61-76)
Clonality
Monoclonal
Clone
[10C4]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Concentration
0.1 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG1
Specificity
Bcl-2
Applications Notes
Bcl-2 Antibody [10C4] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, and immunoprecipitation assays.
Symbol
Bcl2
NCBI Official Name
B cell leukemia/lymphoma 2
NCBI Organism
Mus musculus
Other Product Names
B cell leukemia 2
Tested Applications
Flow
Physical Properties
Liquid
Frequently Asked Questions
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