CD95 Antibody [DX2]
Product Specifications
Background
CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.
NCBI Gene ID
355
Swiss Prot
P25445
Accession Number
P25445
Host
Mouse
Reactivity
Human, Rhesus Monkey, African Green Monkey, Sooty Mangabey
Immunogen
Human CD95 transfected L cells
Clonality
Monoclonal
Clone
[DX2]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Concentration
0.1 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG1
Specificity
CD95
Applications Notes
CD95 Antibody [DX2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, and apoptosis assays.
Symbol
FAS
NCBI Official Name
Tumor necrosis factor receptor superfamily member 6
NCBI Organism
Homo sapiens
Other Product Names
APO-1, Fas, TNFRSF6
Tested Applications
Flow, IP
Physical Properties
Liquid
Frequently Asked Questions
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