CD54 Antibody [15.2]
Product Specifications
Background
CD54, also known as intercellular cell adhesion molecule-1 (ICAM-1), is a 90 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It exhibits a wide tissue distribution being expressed on both hematopoietic and non-hematopoietic cells. ICAM-1 expression on leukocytes is low but is rapidly upregulated upon activation. Expression on endothelium and other non-hematopoietic cells is strongly upregulated by inflammatory mediators. The ligands of CD54 are CD11a/LFA-1alpha and CD11b/Mac-1alpha. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels particularly in areas of inflammation. CD54 on antigen-presenting cells (APC) contributes to antigen-specific T cell activation presumably by enhancing interactions between T cells and APC.
NCBI Gene ID
3383
Swiss Prot
P05362
Accession Number
P05362
Host
Mouse
Reactivity
Human, Pig
Immunogen
Rheumatoid synovial cells and human monocytes
Clonality
Monoclonal
Clone
[15.2]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Concentration
0.1 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG1
Specificity
CD54
Applications Notes
CD54 Antibody [15.2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ELISA, and blocking assays.
Symbol
ICAM1
NCBI Official Name
Intercellular adhesion molecule 1
NCBI Organism
Homo sapiens
Other Product Names
ICAM-1, intracellular adhesion molecule-1, Ly-47
Tested Applications
Flow
Physical Properties
Liquid
Frequently Asked Questions
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