CD49d Antibody [7.2] (FITC)
Product Specifications
Background
CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin alpha4 chain. CD49d associates noncovalently with CD29, the integrin beta1 subunit, to form the alpha4beta1 very late antigen-4 (VLA-4) heterodimer. Integrin alpha4 can also associate with integrin beta7 to form the alpha4beta7 heterodimer. It is expressed on most leukocytes with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106 (VCAM-1) and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The alpha4beta7 integrin heterodimer is expressed on a small subpopulation of thymocytes, most lymph node T and B lymphocytes, NK cells, and eosinophils. Integrin alpha4beta7 also binds to fibronectin and VCAM-1.
NCBI Gene ID
3676
Swiss Prot
P13612
Accession Number
P13612
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
[7.2]
Conjugation
FITC
Type
Primary Antibodies
Field of Research
Immunology
Concentration
Batch dependent
Buffer
Supplied in PBS/NaN3
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=99-386
Fragment
IgG1
Specificity
CD49d
Applications Notes
CD49d Antibody [7.2] for use in flow cytometry, immunocytochemistry, and western blotting assays.
Symbol
ITGA4
NCBI Official Name
Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
NCBI Organism
Homo sapiens
Other Product Names
VLA-4, Integrin alpha4%, VLA-4alpha, ITGA4, IA4
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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