MCAM Antibody [C264]
Product Specifications
Background
Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the third seems to lack transmembrane and cytoplasmic regions. It is highly homologous to gicerin, a molecule involved in neurite outgrowth and Wilm’s kidney tumor progression in the chicken, and to the human melanoma progression molecule MUC18. Chicken MCAM is expressed by c-kit+ hematopoietic progenitor cells in embryonic bone marrow, thymocytes, and capillary endothelial cells. MCAM-expressing cells sorted from bone marrow are enriched in progenitors capable of differentiating into T cells when transferred into the appropriate thymic microenvironment. MCAM has been proposed to be involved in cellular adhesion and homing processes.
NCBI Gene ID
448832
Host
Mouse
Reactivity
Chicken, Turkey
Immunogen
Mixture of E15 and E16 thymocytes from H.B15, H.B19, and H.B21 chicken embryos
Clonality
Monoclonal
Clone
[C264]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=99-302
Fragment
IgG2b
Specificity
MCAM
Applications Notes
MCAM Antibody [C264] for use in flow cytometry, immunocytochemistry, and immunoprecipitation assays.
Symbol
MCAM
NCBI Official Name
Melanoma cell adhesion molecule
NCBI Organism
Gallus gallus
Other Product Names
CD146, HEMCAM, melanoma cell adhesion molecule
Tested Applications
IHC-Fr, Flow, IP
Physical Properties
Liquid
Curated Selection
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