CD8a Antibody [CT-8] (FITC)
Product Specifications
Background
In the chicken, the CD8 molecule is present in two forms - (i) a homodimer of two alpha chains and (ii) a heterodimer of an alpha chain and a beta chain. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8alpha- and CD8beta-chains, a relatively large proportion of the CD8+ TCRgammadelta cells in the spleens of embryos and young chicks express only the alpha-chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved but there is a population of TCRgammadelta CD8alphabeta cells in the chicken that is not found in rodents. Chicken CD8 is expressed on approximately 80% of thymocytes, 15% of blood mononuclear cells, and 50% of spleen cells but less than 1% of cells in the bursa and bone marrow. The monoclonal antibody CT-8 recognizes the CD8alpha chain and has been shown to react to a polymorphic determinant in turkey.
NCBI Gene ID
403158
Host
Mouse
Reactivity
Chicken, Turkey, Guinea Fowl, Pigeon
Immunogen
Chicken thymocytes and Ig-negative blood leukocytes
Clonality
Monoclonal
Clone
[CT-8]
Conjugation
FITC
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in PBS/NaN3
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG1
Specificity
CD8alpha
Applications Notes
CD8a Antibody [CT-8] for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.
Symbol
CD8A
NCBI Official Name
CD8a molecule
NCBI Organism
Gallus gallus
Tested Applications
ELISA, IHC-Fr, Flow, IP, Separation
Physical Properties
Liquid
Curated Selection
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