CD122 Antibody [5H4]
Product Specifications
Background
The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the alpha chain which binds IL-2 with low affinity; (ii) the beta chain that binds IL-2 with high affinity; and (iii) the common gamma chain (gammac) that does not bind IL-2. The high affinity receptor complex is an alpha/beta/gamma heterotrimer with a Kd of 1.3 x 10-11 M. In mouse spleen, CD122 is expresed on ~30% of CD8+ cells and all NK cells but <1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. Cytoplasmic regions of the IL-2R beta chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. The monoclonal antibody 5H4 does not block IL-2 binding.
NCBI Gene ID
16185
Swiss Prot
P16297
Accession Number
P16297
Host
Rat
Reactivity
Mouse
Immunogen
Rat myeloma YB2/0 transfected with truncated IL-2Rbeta cDNA (YB2/0-mbetat-28)
Clonality
Monoclonal
Clone
[5H4]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Concentration
0.5 mg/mL
Buffer
Supplied in PBS
Modification
None
Shipping Conditions
Dry Ice
Storage Conditions
Store vial at -20˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=99-065
Fragment
IgG2a
Specificity
CD122
Applications Notes
CD122 Antibody [5H4] for use in flow cytometry and immunoprecipitation assays.
Symbol
Il2rb
NCBI Official Name
Interleukin 2 receptor, beta chain
NCBI Organism
Mus musculus
Other Product Names
IL-2Rbeta, IL-15 receptor beta chain
Tested Applications
Flow
Physical Properties
Liquid
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