CD104 Antibody [346-11A]
Product Specifications
Background
CD104 represents the integrin beta4 subunit that associates non-covalently with integrin alpha6 (CD49f) to form the alpha6beta4 integrin heterodimer. The alpha6beta4 complex is expressed on the basal surface of a variety of epithelial cell types particularly on stratified squamous epithelia. It is also found in peripheral nerves, in certain subsets of endothelial cells, and on immature thymocytes. It also has been found to be associated with a number of malignant tissues. Hemidesmosomal alpha6beta4 plays an important role in the adhesion of epithelial cells to basement membranes via interactions with laminin and/or kalinin anchoring filaments. It is not known if the monoclonal antibody 346-11A can block this adhesion.
NCBI Gene ID
192897
Swiss Prot
A2A863
Accession Number
A2A863
Host
Rat
Reactivity
Mouse
Immunogen
Tumor-associated antigen TSP-180 purified from a transplantable BALB/c carcinoma
Clonality
Monoclonal
Clone
[346-11A]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2a
Specificity
CD104
Applications Notes
CD104 Antibody [346-11A] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, and immunoprecipitation assays.
Symbol
Itgb4
NCBI Official Name
Integrin beta 4
NCBI Organism
Mus musculus
Other Product Names
Integrin beta4
Tested Applications
IHC-P, IHC-Fr, ICC, Flow, IP
Physical Properties
Liquid
Curated Selection
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