CD81 Antibody [2F7]
Product Specifications
Background
CD81, also known as TAPA-1, is an integral membrane protein expressed on a variety of cell types and has a high degree of sequence homology between human and mouse. CD81 is expressed on thymic stromal cells where it plays an important role in the transition of gammadelta+ T cells to more mature T cells with alphabeta T cell receptors. Immunohistochemical staining has revealed that its expression is localized to the subcapsular region of the thymus and, specifically, on cells that have distinct clustering patterns. It has been speculated that the ligand for CD81 is the pre-T cell receptor which is composed of a TCR beta chain and glycoprotein pTalpha. The monoclonal antibody 2F7 can block thymocyte interaction with CD81 in vitro.
NCBI Gene ID
12520
Swiss Prot
P35762
Accession Number
P35762
Host
Hamster
Reactivity
Mouse
Immunogen
Mouse epithelial cell line PAM212
Clonality
Monoclonal
Clone
[2F7]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-990
Fragment
IgG
Specificity
CD81
Applications Notes
CD81 Antibody [2F7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, costimulation, and blocking assays.
Symbol
Cd81
NCBI Official Name
CD81 antigen
NCBI Organism
Mus musculus
Other Product Names
TAPA-1
Tested Applications
WB, IHC-Fr, Flow
Physical Properties
Liquid
Curated Selection
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