KLRG1 Antibody [2F1] (PE)
Product Specifications
Background
The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL) . Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.
NCBI Gene ID
50928
Swiss Prot
O88713
Accession Number
O88713
Host
Hamster
Reactivity
Mouse, Human
Immunogen
IL-2-activated NK cells (A-LAK cells) from B6 (H-2b) mice
Clonality
Monoclonal
Clone
[2F1]
Conjugation
PE
Type
Primary Antibodies
Field of Research
Innate Immunity, Immunology
Concentration
0.1 mg/mL
Buffer
Supplied in PBS/NaN3 and a stabilizing agent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG
Specificity
KLRG1
Applications Notes
KLRG1 Antibody [2F1] for use in flow cytometry assays.
Symbol
Klrg1
NCBI Official Name
Killer cell lectin-like receptor subfamily G, member 1
NCBI Organism
Mus musculus
Other Product Names
MAFA, killer cell lectin-like receptor G1, mast cell function-associated-antigen
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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