CD49b Antibody [DX5] (PE)
Product Specifications
Background
The monoclonal antibody DX5 reacts with CD49b, also known as very late antigen-2 (VLA-2) and alpha2 integrin. The antibody stains the majority of NK cells and a small subpopulation of T cells in all mouse strains tested (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, CBA/J, DBA/1, DBA/2, SJL, SWR) . Three-color flow cytometry analysis has revealed that most cells that express NK-1.1 (NKR-P1C) also express CD49b. However, small subsets of DX5+NK-1.1- and DX5-NK-1.1+ cells can be found, especially among the CD3+ population of T lymphocytes. NK cells cultured in the presence of IL-2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. The monoclonal antibody DX5 has not been demonstrated to have activating or blocking activity.
NCBI Gene ID
16398
Swiss Prot
Q62469
Accession Number
Q62469
Host
Rat
Reactivity
Mouse
Immunogen
NK cells isolated from C57BL/6 mice
Clonality
Monoclonal
Clone
[DX5]
Conjugation
PE
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.1 mg/mL
Buffer
Supplied in PBS/NaN3 and a stabilizing agent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgM
Specificity
CD49b
Applications Notes
CD49b Antibody [DX5] for use in flow cytometry assays.
Symbol
Itga2
NCBI Official Name
Integrin alpha 2
NCBI Organism
Mus musculus
Other Product Names
Alpha2 integrin, VLA-2alpha, very late antigen-2, pan NK
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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