Ly-49C/F/H/I Antibody [14B11]
Product Specifications
Background
The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J) .
NCBI Gene ID
16634;16637;16639;16640
Swiss Prot
Q64329
Accession Number
Q64329
Host
Hamster
Reactivity
Mouse
Immunogen
IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice
Clonality
Monoclonal
Clone
[14B11]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-934
Fragment
IgG
Specificity
Ly-49C/F/H/I
Applications Notes
Ly-49C/F/H/I Antibody [14B11] for use in flow cytometry and cytotoxicity assays.
Symbol
Klra3
NCBI Official Name
Killer cell lectin-like receptor, subfamily A, member 3
NCBI Organism
Mus musculus
Other Product Names
Ly-49
Tested Applications
WB, IHC-P, IHC-Fr, ICC, Flow
Physical Properties
Liquid
Curated Selection
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