CD45.1 Antibody [A20] (PE-Cy7)
Product Specifications
Background
The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosphorylate the Src family of protein kinases. This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685, and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2) . The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD45.1 allotype.
NCBI Gene ID
19264
Swiss Prot
P06800
Accession Number
P06800
Host
Mouse
Reactivity
Mouse
Immunogen
SJL mouse thymocytes and splenocytes
Clonality
Monoclonal
Clone
[A20]
Conjugation
PE-Cy7
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.1 mg/mL
Buffer
Supplied in PBS/NaN3 and a stabilizing agent
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-921
Fragment
IgG2a
Specificity
CD45.1
Applications Notes
CD45.1 Antibody [A20] for use in flow cytometry assays.
Symbol
Ptprc
NCBI Official Name
Protein tyrosine phosphatase, receptor type, C
NCBI Organism
Mus musculus
Other Product Names
Ly-5.1, LCA, SJL, T200
Tested Applications
WB, ICC, Flow, IP
Physical Properties
Liquid
Curated Selection
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