CD152 Antibody [9H10]
Product Specifications
Background
CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
NCBI Gene ID
12477
Swiss Prot
P09793
Accession Number
P09793
Host
Hamster
Reactivity
Mouse
Immunogen
Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
Clonality
Monoclonal
Clone
[9H10]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG
Specificity
CD152
Applications Notes
CD152 Antibody [9H10] for use in flow cytometry, ELISA, blocking, and costimulation assays.
Symbol
Ctla4
NCBI Official Name
Cytotoxic T-lymphocyte-associated protein 4
NCBI Organism
Mus musculus
Other Product Names
CTLA-4, cytotoxic T-lymphocyte protein 4
Tested Applications
IHC-Fr, ICC, Flow, Separation
Physical Properties
Liquid
Frequently Asked Questions
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