Ly-6A/E Antibody [D7]
Product Specifications
Background
Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.
NCBI Gene ID
110454
Swiss Prot
P05533
Accession Number
P05533
Host
Rat
Reactivity
Mouse
Immunogen
IL-2 dependent mouse (C57BL/6) cytotoxic T cell line CTL-L
Clonality
Monoclonal
Clone
[D7]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity, Stem Cell
Concentration
0.5 mg/mL
Buffer
Supplied in PBS
Modification
None
Shipping Conditions
Dry Ice
Storage Conditions
Store vial at -20˚ C
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=98-880
Fragment
IgG2a
Specificity
Ly-6A/E
Applications Notes
Ly-6A/E Antibody [D7] for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, and costimulation assays.
Symbol
Ly6a
NCBI Official Name
Lymphocyte antigen 6 complex, locus A
NCBI Organism
Mus musculus
Other Product Names
Sca-1
Tested Applications
WB, IHC-Fr, ICC, Flow
Physical Properties
Liquid
Curated Selection
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